Radio-interferometric (RI) imaging entails solving high-resolution high-dynamic range inverse problems from large data volumes. Recent image reconstruction techniques grounded in optimization theory have demonstrated remarkable capability for imaging precision, well beyond CLEAN's capability. These range from advanced proximal algorithms propelled by handcrafted regularization operators, such as the SARA family, to hybrid plug-and-play (PnP) algorithms propelled by learned regularization denoisers, such as AIRI. Optimization and PnP structures are however highly iterative, which hinders their ability to handle the extreme data sizes expected from future instruments. To address this scalability challenge, we introduce a novel deep learning approach, dubbed ``Residual-to-Residual DNN series for high-Dynamic range imaging''. R2D2's reconstruction is formed as a series of residual images, iteratively estimated as outputs of Deep Neural Networks (DNNs) taking the previous iteration's image estimate and associated data residual as inputs. It thus takes a hybrid structure between a PnP algorithm and a learned version of the matching pursuit algorithm that underpins CLEAN. We present a comprehensive study of our approach, featuring its multiple incarnations distinguished by their DNN architectures. We provide a detailed description of its training process, targeting a telescope-specific approach. R2D2's capability to deliver high precision is demonstrated in simulation, across a variety of image and observation settings using the Very Large Array (VLA). Its reconstruction speed is also demonstrated: with only few iterations required to clean data residuals at dynamic ranges up to 100000, R2D2 opens the door to fast precision imaging. R2D2 codes are available in the BASPLib library on GitHub.