Large Language Model (LLM) applications, including LLM app stores and autonomous agents, are shaping the future of AI ecosystems. However, platform silos, fragmented hardware integration, and the absence of standardized interfaces limit scalability, interoperability, and resource efficiency. While LLM app stores democratize AI, their closed ecosystems restrict modular AI reuse and cross-platform portability. Meanwhile, agent-based frameworks offer flexibility but often lack seamless integration across diverse environments. This paper envisions the future of LLM applications and proposes a three-layer decoupled architecture grounded in software engineering principles such as layered system design, service-oriented architectures, and hardware-software co-design. This architecture separates application logic, communication protocols, and hardware execution, enhancing modularity, efficiency, and cross-platform compatibility. Beyond architecture, we highlight key security and privacy challenges for safe, scalable AI deployment and outline research directions in software and security engineering. This vision aims to foster open, secure, and interoperable LLM ecosystems, guiding future advancements in AI applications.