Stain-Robust Mitotic Figure Detection for MIDOG 2022 Challenge

The detection of mitotic figures from different scanners/sites remains an important topic of research, owing to its potential in assisting clinicians with tumour grading. The MItosis DOmain Generalization (MIDOG) 2022 challenge aims to test the robustness of detection models on unseen data from multiple scanners and tissue types for this task. We present a short summary of the approach employed by the TIA Centre team to address this challenge. Our approach is based on a hybrid detection model, where mitotic candidates are segmented, before being refined by a deep learning classifier. Cross-validation on the training images achieved the F1-score of 0.816 and 0.784 on the preliminary test set, demonstrating the generalizability of our model to unseen data from new scanners.