We introduce SketchySGD, a stochastic quasi-Newton method that uses sketching to approximate the curvature of the loss function. Quasi-Newton methods are among the most effective algorithms in traditional optimization, where they converge much faster than first-order methods such as SGD. However, for contemporary deep learning, quasi-Newton methods are considered inferior to first-order methods like SGD and Adam owing to higher per-iteration complexity and fragility due to inexact gradients. SketchySGD circumvents these issues by a novel combination of subsampling, randomized low-rank approximation, and dynamic regularization. In the convex case, we show SketchySGD with a fixed stepsize converges to a small ball around the optimum at a faster rate than SGD for ill-conditioned problems. In the non-convex case, SketchySGD converges linearly under two additional assumptions, interpolation and the Polyak-Lojaciewicz condition, the latter of which holds with high probability for wide neural networks. Numerical experiments on image and tabular data demonstrate the improved reliability and speed of SketchySGD for deep learning, compared to standard optimizers such as SGD and Adam and existing quasi-Newton methods.