Current large language models (LLMs) primarily utilize next-token prediction method for inference, which significantly impedes their processing speed. In this paper, we introduce a novel inference methodology termed next-sentence prediction, aimed at enhancing the inference efficiency of LLMs. We present Sentence Variational Autoencoder (SentenceVAE), a tiny model consisting of a Sentence Encoder and a Sentence Decoder. The Sentence Encoder can effectively condense the information within a sentence into a singular token, while the Sentence Decoder can reconstruct this compressed token back into sentence. By integrating SentenceVAE into the input and output layers of LLMs, we develop Sentence-level LLMs (SLLMs) that employ a sentence-by-sentence inference method. In addition, the SentenceVAE module of SLLMS can maintain the integrity of the original semantic content by segmenting the context into sentences, thereby improving accuracy while boosting inference speed. Moreover, compared to previous LLMs, SLLMs process fewer tokens over equivalent context length, significantly reducing memory demands for self-attention computation and facilitating the handling of longer context. Extensive experiments on Wanjuan dataset have reveal that the proposed method can accelerate inference speed by 204~365%, reduce perplexity (PPL) to 46~75% of its original metric, and decrease memory overhead by 86~91% for the equivalent context length, compared to the token-by-token method.