Communication-centric Integrated Sensing and Communication (ISAC) has been recognized as a promising methodology to implement wireless sensing functionality over existing network architectures, due to its cost-effectiveness and backward compatibility to legacy cellular systems. However, the inherent randomness of the communication signal may incur huge fluctuations in sensing capabilities, leading to unfavorable detection and estimation performance. To address this issue, we elaborate on random ISAC signal processing methods in this article, aiming at improving the sensing performance without unduly deteriorating the communication functionality. Specifically, we commence by discussing the fundamentals of sensing with random communication signals, including the performance metrics and optimal ranging waveforms. Building on these concepts, we then present a general framework for random ISAC signal transmission, followed by an in-depth exploration of time-domain pulse shaping, frequency-domain constellation shaping, and spatial-domain precoding methods. We provide a comprehensive overview of each of these topics, including models, results, and design guidelines. Finally, we conclude this article by identifying several promising research directions for random ISAC signal transmission.