Federated learning (FL) enables massive distributed Information and Communication Technology (ICT) devices to learn a global consensus model without any participants revealing their own data to the central server. However, the practicality, communication expense and non-independent and identical distribution (Non-IID) data challenges in FL still need to be concerned. In this work, we propose the Semi-Federated Learning (Semi-FL) which differs from the FL in two aspects, local clients clustering and in-cluster training. A sequential training manner is designed for our in-cluster training in this paper which enables the neighboring clients to share their learning models. The proposed Semi-FL can be easily applied to future mobile communication networks and require less up-link transmission bandwidth. Numerical experiments validate the feasibility, learning performance and the robustness to Non-IID data of the proposed Semi-FL. The Semi-FL extends the existing potentials of FL.