Representation Learning in real-world class-imbalanced settings has emerged as a challenging task in the evolution of deep learning. Lack of diversity in visual and structural features for rare classes restricts modern neural networks to learn discriminative feature clusters. This manifests in the form of large inter-class bias between rare object classes and elevated intra-class variance among abundant classes in the dataset. Although deep metric learning approaches have shown promise in this domain, significant improvements need to be made to overcome the challenges associated with class-imbalance in mission critical tasks like autonomous navigation and medical diagnostics. Set-based combinatorial functions like Submodular Information Measures exhibit properties that allow them to simultaneously model diversity and cooperation among feature clusters. In this paper, we introduce the SCoRe (Submodular Combinatorial Representation Learning) framework and propose a family of Submodular Combinatorial Loss functions to overcome these pitfalls in contrastive learning. We also show that existing contrastive learning approaches are either submodular or can be re-formulated to create their submodular counterparts. We conduct experiments on the newly introduced family of combinatorial objectives on two image classification benchmarks - pathologically imbalanced CIFAR-10, subsets of MedMNIST and a real-world road object detection benchmark - India Driving Dataset (IDD). Our experiments clearly show that the newly introduced objectives like Facility Location, Graph-Cut and Log Determinant outperform state-of-the-art metric learners by up to 7.6% for the imbalanced classification tasks and up to 19.4% for object detection tasks.