Reference-based OCT Angiogram Super-resolution with Learnable Texture Generation

Optical coherence tomography angiography (OCTA) is a new imaging modality to visualize retinal microvasculature and has been readily adopted in clinics. High-resolution OCT angiograms are important to qualitatively and quantitatively identify potential biomarkers for different retinal diseases accurately. However, one significant problem of OCTA is the inevitable decrease in resolution when increasing the field-of-view given a fixed acquisition time. To address this issue, we propose a novel reference-based super-resolution (RefSR) framework to preserve the resolution of the OCT angiograms while increasing the scanning area. Specifically, textures from the normal RefSR pipeline are used to train a learnable texture generator (LTG), which is designed to generate textures according to the input. The key difference between the proposed method and traditional RefSR models is that the textures used during inference are generated by the LTG instead of being searched from a single reference image. Since the LTG is optimized throughout the whole training process, the available texture space is significantly enlarged and no longer limited to a single reference image, but extends to all textures contained in the training samples. Moreover, our proposed LTGNet does not require a reference image at the inference phase, thereby becoming invulnerable to the selection of the reference image. Both experimental and visual results show that LTGNet has superior performance and robustness over state-of-the-art methods, indicating good reliability and promise in real-life deployment. The source code will be made available upon acceptance.