This paper leverages the potential of Large Intelligent Surface (LIS) for radio sensing in 6G wireless networks. Major research has been undergone about its communication capabilities but it can be exploited as a formidable tool for radio sensing. By taking advantage of arbitrary communication signals occurring in the scenario, we apply a Matched Filtering (MF) processing to the output signal from the LIS to obtain a radio map that describes the physical presence of passive devices (scatterers, humans) which act as virtual sources due to the communication signal reflections. We then assess the usage of machine learning (k-means clustering), image processing and computer vision (template matching and component labeling) to extract meaningful information from these radio maps. As an exemplary use case, we evaluate this method for both active and passive user detection in an indoor setting. The results show that the presented method has high application potential as we are able to detect around 98% of humans passively and 100% active users by just using communication signals of commodity devices even in quite unfavorable Signal-to-Noise Ratio (SNR) conditions.