Diffusion Models have emerged as powerful generative models for high-quality image synthesis, with many subsequent image editing techniques based on them. However, the ease of text-based image editing introduces significant risks, such as malicious editing for scams or intellectual property infringement. Previous works have attempted to safeguard images from diffusion-based editing by adding imperceptible perturbations. These methods are costly and specifically target prevalent Latent Diffusion Models (LDMs), while Pixel-domain Diffusion Models (PDMs) remain largely unexplored and robust against such attacks. Our work addresses this gap by proposing a novel attacking framework with a feature representation attack loss that exploits vulnerabilities in denoising UNets and a latent optimization strategy to enhance the naturalness of protected images. Extensive experiments demonstrate the effectiveness of our approach in attacking dominant PDM-based editing methods (e.g., SDEdit) while maintaining reasonable protection fidelity and robustness against common defense methods. Additionally, our framework is extensible to LDMs, achieving comparable performance to existing approaches.