Panoramic X-ray and Cone Beam Computed Tomography (CBCT) are two of the most general imaging methods in digital dentistry. While CBCT can provide higher-dimension information, the panoramic X-ray has the advantages of lower radiation dose and cost. Consequently, generating 3D information of bony tissues from the X-ray that can reflect dental diseases is of great interest. This technique can be even more helpful for developing areas where the CBCT is not always available due to the lack of screening machines or high screening cost. In this paper, we present \textit{Oral-3D} to reconstruct the bone structure of oral cavity from a single panoramic X-ray image by taking advantage of some prior knowledge in oral structure, which conventionally can only be obtained by a 3D imaging method like CBCT. Specifically, we first train a generative network to back project the 2D X-ray image into 3D space, then restore the bone structure by registering the generated 3D image with the prior shape of the dental arch. To be noted, \textit{Oral-3D} can restore both the density of bony tissues and the curved mandible surface. Experimental results show that our framework can reconstruct the 3D structure with significantly high quality. To the best of our knowledge, this is the first work that explores 3D reconstruction from a 2D image in dental health.