Rapid advances in artificial intelligence (AI) have the potential to significantly increase the productivity, quality, and profitability in future manufacturing systems. Traditional mass-production will give way to personalized production, with each item made to order, at the low cost and high-quality consumers have come to expect. Manufacturing systems will have the intelligence to be resilient to multiple disruptions, from small-scale machine breakdowns, to large-scale natural disasters. Products will be made with higher precision and lower variability. While gains have been made towards the development of these factories of the future, many challenges remain to fully realize this vision. To consider the challenges and opportunities associated with this topic, a panel of experts from Industry, Academia, and Government was invited to participate in an active discussion at the 2022 Modeling, Estimation and Control Conference (MECC) held in Jersey City, New Jersey from October 3- 5, 2022. The panel discussion focused on the challenges and opportunities to more fully integrate AI into manufacturing systems. Three overarching themes emerged from the panel discussion. First, to be successful, AI will need to work seamlessly, and in an integrated manner with humans (and vice versa). Second, significant gaps in the infrastructure needed to enable the full potential of AI into the manufacturing ecosystem, including sufficient data availability, storage, and analysis, must be addressed. And finally, improved coordination between universities, industry, and government agencies can facilitate greater opportunities to push the field forward. This article briefly summarizes these three themes, and concludes with a discussion of promising directions.