Self Organizing Migrating Algorithm (SOMA) is a meta-heuristic algorithm based on the self-organizing behavior of individuals in a simulated social environment. SOMA performs iterative computations on a population of potential solutions in the given search space to obtain an optimal solution. In this paper, an Opportunistic Self Organizing Migrating Algorithm (OSOMA) has been proposed that introduces a novel strategy to generate perturbations effectively. This strategy allows the individual to span across more possible solutions and thus, is able to produce better solutions. A comprehensive analysis of OSOMA on multi-dimensional unconstrained benchmark test functions is performed. OSOMA is then applied to solve real-time Dynamic Traveling Salesman Problem (DTSP). The problem of real-time DTSP has been stipulated and simulated using real-time data from Google Maps with a varying cost-metric between any two cities. Although DTSP is a very common and intuitive model in the real world, its presence in literature is still very limited. OSOMA performs exceptionally well on the problems mentioned above. To substantiate this claim, the performance of OSOMA is compared with SOMA, Differential Evolution and Particle Swarm Optimization.