The advances in the automotive industry with the ever-increasing request for Connected and Autonomous Vehicles (CAVs) are pushing for a new epoch of networked wireless systems. Vehicular communications, or Vehicle-to-Everything (V2X), are expected to be among the main actors of the future beyond 5G and 6G networks. However, the challenging application requirements, the fast variability of the vehicular environment, and the harsh propagation conditions of high frequencies call for sophisticated control mechanisms to ensure the success of such a disruptive technology. While traditional Radio Access Networks (RAN) lack the flexibility to support the required control primitives, the emergent concept of Open RAN (O-RAN) appears as an ideal enabler of V2X communication orchestration. However, how to effectively integrate the two ecosystems is still an open issue. In this position paper, we discuss possible integration strategies, highlighting the challenges and opportunities of leveraging O-RAN to enable real-time V2X control. Additionally, we enrich our discussion with potential research directions stemming from the current state-of-the-art and we give an overview of the simulation tools that can be employed to facilitate investigations on this topic