Neighboring Slice Noise2Noise: Self-Supervised Medical Image Denoising from Single Noisy Image Volume

In the last few years, with the rapid development of deep learning technologies, supervised methods based on convolutional neural networks have greatly enhanced the performance of medical image denoising. However, these methods require large quantities of noisy-clean image pairs for training, which greatly limits their practicality. Although some researchers have attempted to train denoising networks using only single noisy images, existing self-supervised methods, including blind-spot-based and data-splitting-based methods, heavily rely on the assumption that noise is pixel-wise independent. However, this assumption often does not hold in real-world medical images. Therefore, in the field of medical imaging, there remains a lack of simple and practical denoising methods that can achieve high-quality denoising performance using only single noisy images. In this paper, we propose a novel self-supervised medical image denoising method, Neighboring Slice Noise2Noise (NS-N2N). The proposed method utilizes neighboring slices within a single noisy image volume to construct weighted training data, and then trains the denoising network using a self-supervised scheme with regional consistency loss and inter-slice continuity loss. NS-N2N only requires a single noisy image volume obtained from one medical imaging procedure to achieve high-quality denoising of the image volume itself. Extensive experiments demonstrate that the proposed method outperforms state-of-the-art self-supervised denoising methods in both denoising performance and processing efficiency. Furthermore, since NS-N2N operates solely in the image domain, it is free from device-specific issues such as reconstruction geometry, making it easier to apply in various clinical practices.