Direct Preference Optimization (DPO) has recently emerged as a popular approach to improve reinforcement learning with human feedback (RLHF), leading to better techniques to fine-tune large language models (LLM). A weakness of DPO, however, lies in its lack of capability to characterize the diversity of human preferences. Inspired by Mallows' theory of preference ranking, we develop in this paper a new approach, the Mallows-DPO. A distinct feature of this approach is a dispersion index, which reflects the dispersion of human preference to prompts. We show that existing DPO models can be reduced to special cases of this dispersion index, thus unified with Mallows-DPO. More importantly, we demonstrate (empirically) how to use this dispersion index to enhance the performance of DPO in a broad array of benchmark tasks, from synthetic bandit selection to controllable generations and dialogues, while maintaining great generalization capabilities.