Large Language Models (LLMs) have demonstrated remarkable capability in a variety of NLP tasks. Despite their effectiveness, these models are prone to generate nonfactual content. Uncertainty Quantification (UQ) is pivotal in enhancing our understanding of a model's confidence in its generated content, thereby aiding in the mitigation of nonfactual outputs. Existing research on UQ predominantly targets short text generation, typically yielding brief, word-limited responses. However, real-world applications frequently necessitate much longer responses. Our study first highlights the limitations of current UQ methods in handling long text generation. We then introduce \textsc{Luq}, a novel sampling-based UQ approach specifically designed for long text. Our findings reveal that \textsc{Luq} outperforms existing baseline methods in correlating with the model's factuality scores (negative coefficient of -0.85 observed for Gemini Pro). With \textsc{Luq} as the tool for UQ, we investigate behavior patterns of several popular LLMs' response confidence spectrum and how that interplays with the response' factuality. We identify that LLMs lack confidence in generating long text for rare facts and a factually strong model (i.e. GPT-4) tends to reject questions it is not sure about. To further improve the factual accuracy of LLM responses, we propose a method called \textsc{Luq-Ensemble} that ensembles responses from multiple models and selects the response with the least uncertainty. The ensembling method greatly improves the response factuality upon the best standalone LLM.