The ever-increasing data traffic, various delay-sensitive services, and the massive deployment of energy-limited Internet of Things (IoT) devices have brought huge challenges to the current communication networks, motivating academia and industry to move to the sixth-generation (6G) network. With the powerful capability of data transmission and processing, 6G is considered as an enabler for IoT communication with low latency and energy cost. In this paper, we propose an artificial intelligence (AI) and intelligent reflecting surface (IRS) empowered energy-efficiency communication system for 6G IoT. First, we design a smart and efficient communication architecture including the IRS-aided data transmission and the AI-driven network resource management mechanisms. Second, an energy efficiency-maximizing model under given transmission latency for 6G IoT system is formulated, which jointly optimizes the settings of all communication participants, i.e. IoT transmission power, IRS-reflection phase shift, and BS detection matrix. Third, a deep reinforcement learning (DRL) empowered network resource control and allocation scheme is proposed to solve the formulated optimization model. Based on the network and channel status, the DRL-enabled scheme facilities the energy-efficiency and low-latency communication. Finally, experimental results verified the effectiveness of our proposed communication system for 6G IoT.