Knowledge-Driven Learning via Experts Consult for Thyroid Nodule Classification

Computer-aided diagnosis (CAD) is becoming a prominent approach to assist clinicians spanning across multiple fields. These automated systems take advantage of various computer vision (CV) procedures, as well as artificial intelligence (AI) techniques, so that a diagnosis of a given image (e.g., computed tomography and ultrasound) can be formulated. Advances in both areas (CV and AI) are enabling ever increasing performances of CAD systems, which can ultimately avoid performing invasive procedures such as fine-needle aspiration. In this study, we focus on thyroid ultrasonography to present a novel knowledge-driven classification framework. The proposed system leverages cues provided by an ensemble of experts, in order to guide the learning phase of a densely connected convolutional network (DenseNet). The ensemble is composed by various networks pretrained on ImageNet, including AlexNet, ResNet, VGG, and others, so that previously computed feature parameters could be used to create ultrasonography domain experts via transfer learning, decreasing, moreover, the number of samples required for training. To validate the proposed method, extensive experiments were performed, providing detailed performances for both the experts ensemble and the knowledge-driven DenseNet. The obtained results, show how the the proposed system can become a great asset when formulating a diagnosis, by leveraging previous knowledge derived from a consult.