As language technologies become widespread, it is important to understand how variations in language affect reader perceptions -- formalized as the isolated causal effect of some focal language-encoded intervention on an external outcome. A core challenge of estimating isolated effects is the need to approximate all non-focal language outside of the intervention. In this paper, we introduce a formal estimation framework for isolated causal effects and explore how different approximations of non-focal language impact effect estimates. Drawing on the principle of omitted variable bias, we present metrics for evaluating the quality of isolated effect estimation and non-focal language approximation along the axes of fidelity and overlap. In experiments on semi-synthetic and real-world data, we validate the ability of our framework to recover ground truth isolated effects, and we demonstrate the utility of our proposed metrics as measures of quality for both isolated effect estimates and non-focal language approximations.