Graph-based regularization for regression problems with highly-correlated designs

Sparse models for high-dimensional linear regression and machine learning have received substantial attention over the past two decades. Model selection, or determining which features or covariates are the best explanatory variables, is critical to the interpretability of a learned model. Much of the current literature assumes that covariates are only mildly correlated. However, in modern applications ranging from functional MRI to genome-wide association studies, covariates are highly correlated and do not exhibit key properties (such as the restricted eigenvalue condition, RIP, or other related assumptions). This paper considers a high-dimensional regression setting in which a graph governs both correlations among the covariates and the similarity among regression coefficients. Using side information about the strength of correlations among features, we form a graph with edge weights corresponding to pairwise covariances. This graph is used to define a graph total variation regularizer that promotes similar weights for highly correlated features. The graph structure encapsulated by this regularizer helps precondition correlated features to yield provably accurate estimates. Using graph-based regularizers to develop theoretical guarantees for highly-correlated covariates has not been previously examined. This paper shows how our proposed graph-based regularization yields mean-squared error guarantees for a broad range of covariance graph structures and correlation strengths which in many cases are optimal by imposing additional structure on $\beta^{\star}$ which encourages \emph{alignment} with the covariance graph. Our proposed approach outperforms other state-of-the-art methods for highly-correlated design in a variety of experiments on simulated and real fMRI data.