This paper presents Domain-Specific Sub-network (DoSS). It uses a set of masks obtained through pruning to define a sub-network for each domain and finetunes the sub-network parameters on domain data. This performs very closely and drastically reduces the number of parameters compared to finetuning the whole network on each domain. Also a method to make masks unique per domain is proposed and shown to greatly improve the generalization to unseen domains. In our experiments on German to English machine translation the proposed method outperforms the strong baseline of continue training on multi-domain (medical, tech and religion) data by 1.47 BLEU points. Also continue training DoSS on new domain (legal) outperforms the multi-domain (medical, tech, religion, legal) baseline by 1.52 BLEU points.