In recent years, conversational large language models (LLMs) have shown tremendous success in tasks such as casual conversation, question answering, and personalized dialogue, making significant advancements in domains like virtual assistance, social interaction, and online customer engagement. However, they often generate responses that are not aligned with human values (e.g., ethical standards, safety, or social norms), leading to potentially unsafe or inappropriate outputs. While several techniques have been proposed to address this problem, they come with a cost, requiring computationally expensive training or dramatically increasing the inference time. In this paper, we present DIESEL, a lightweight inference guidance technique that can be seamlessly integrated into any autoregressive LLM to semantically filter undesired concepts from the response. DIESEL can function either as a standalone safeguard or as an additional layer of defense, enhancing response safety by reranking the LLM's proposed tokens based on their similarity to predefined negative concepts in the latent space. This approach provides an efficient and effective solution for maintaining alignment with human values. Our evaluation demonstrates DIESEL's effectiveness on state-of-the-art conversational models (e.g., Llama 3), even in challenging jailbreaking scenarios that test the limits of response safety. We further show that DIESEL can be generalized to use cases other than safety, providing a versatile solution for general-purpose response filtering with minimal computational overhead.