Hazard detection and avoidance is a key technology for future robotic small body sample return and lander missions. Current state-of-the-practice methods rely on high-fidelity, a priori terrain maps, which require extensive human-in-the-loop verification and expensive reconnaissance campaigns to resolve mapping uncertainties. We propose a novel safety mapping paradigm that leverages deep semantic segmentation techniques to predict landing safety directly from a single monocular image, thus reducing reliance on high-fidelity, a priori data products. We demonstrate precise and accurate safety mapping performance on real in-situ imagery of prospective sample sites from the OSIRIS-REx mission.