Manual engineering of high-performance implementations typically consumes many resources and requires in-depth knowledge of the hardware. Compilers try to address these problems; however, they are limited by design in what they can do. To address this, we present CryptOpt, an automatic optimizer for long stretches of straightline code. Experimental results across eight hardware platforms show that CryptOpt achieves a speed-up factor of up to 2.56 over current off-the-shelf compilers.