The traditional methods for data compression are typically based on the symbol-level statistics, with the information source modeled as a long sequence of i.i.d. random variables or a stochastic process, thus establishing the fundamental limit as entropy for lossless compression and as mutual information for lossy compression. However, the source (including text, music, and speech) in the real world is often statistically ill-defined because of its close connection to human perception, and thus the model-driven approach can be quite suboptimal. This study places careful emphasis on English text and exploits its semantic aspect to enhance the compression efficiency further. The main idea stems from the puzzle crossword, observing that the hidden words can still be precisely reconstructed so long as some key letters are provided. The proposed masking-based strategy resembles the above game. In a nutshell, the encoder evaluates the semantic importance of each word according to the semantic loss and then masks the minor ones, while the decoder aims to recover the masked words from the semantic context by means of the Transformer. Our experiments show that the proposed semantic approach can achieve much higher compression efficiency than the traditional methods such as Huffman code and UTF-8 code, while preserving the meaning in the target text to a great extent.