Responsibility is one of the key notions in machine ethics and in the area of autonomous systems. It is a multi-faceted notion involving counterfactual reasoning about actions and strategies. In this paper, we study different variants of responsibility in a strategic setting based on LTLf. We show a connection with notions in reactive synthesis, including synthesis of winning, dominant, and best-effort strategies. This connection provides the building blocks for a computational grounding of responsibility including complexity characterizations and sound, complete, and optimal algorithms for attributing and anticipating responsibility.