Contrastive Language-Image Pre-training (CLIP) excels in integrating semantic information between images and text through contrastive learning techniques. It has achieved remarkable performance in various multimodal tasks. However, the deployment of large CLIP models is hindered in resource-limited environments, while smaller models frequently fall short of meeting performance benchmarks necessary for practical applications. In this paper, we propose a novel approach, coined as ComKD-CLIP: Comprehensive Knowledge Distillation for Contrastive Language-Image Pre-traning Model, which aims to comprehensively distill the knowledge from a large teacher CLIP model into a smaller student model, ensuring comparable performance with significantly reduced parameters. ComKD-CLIP is composed of two key mechanisms: Image Feature Alignment (IFAlign) and Educational Attention (EduAttention). IFAlign makes the image features extracted by the student model closely match those extracted by the teacher model, enabling the student to learn teacher's knowledge of extracting image features. EduAttention explores the cross-relationships between text features extracted by the teacher model and image features extracted by the student model, enabling the student model to learn how the teacher model integrates text-image features. In addition, ComKD-CLIP can refine the knowledge distilled from IFAlign and EduAttention leveraging the results of text-image feature fusion by the teacher model, ensuring student model accurately absorbs the knowledge of teacher model. Extensive experiments conducted on 11 datasets have demonstrated the superiority of the proposed method.