In this paper, we propose a novel strategy defined as Chain-of-Description (CoD) Prompting, tailored for Multi-Modal Large Language Models. This approach involves having the model first provide a detailed description of the multi-modal input before generating an answer to the question. When applied to models such as Qwen2-Audio, Qwen2-VL, and Qwen2.5-VL, CoD Prompting significantly enhances performance compared to standard prompting methods. This is demonstrated by nearly a 4\% improvement in the speech category of the audio benchmark AIR-Bench-Chat and a 5.3\% improvement in the hard-level portion of the vision benchmark MMMU\_Pro. Our ablation study further validates the effectiveness of CoD Prompting.