Spectral unmixing has been extensively studied with a variety of methods and used in many applications. Recently, data-driven techniques with deep learning methods have obtained great attention to spectral unmixing for its superior learning ability to automatically learn the structure information. In particular, autoencoder based architectures are elaborately designed to solve blind unmixing and model complex nonlinear mixtures. Nevertheless, these methods perform unmixing task as blackboxes and lack of interpretability. On the other hand, conventional unmixing methods carefully design the regularizer to add explicit information, in which algorithms such as plug-and-play (PnP) strategies utilize off-the-shelf denoisers to plug powerful priors. In this paper, we propose a generic unmixing framework to integrate the autoencoder network with regularization by denoising (RED), named AE-RED. More specially, we decompose the unmixing optimized problem into two subproblems. The first one is solved using deep autoencoders to implicitly regularize the estimates and model the mixture mechanism. The second one leverages the denoiser to bring in the explicit information. In this way, both the characteristics of the deep autoencoder based unmixing methods and priors provided by denoisers are merged into our well-designed framework to enhance the unmixing performance. Experiment results on both synthetic and real data sets show the superiority of our proposed framework compared with state-of-the-art unmixing approaches.