Generative AI applications are recently catering to a vast user base by creating diverse and high-quality AI-generated content (AIGC). With the proliferation of mobile devices and rapid growth of mobile traffic, providing ubiquitous access to high-quality AIGC services via wireless communication networks is becoming the future direction for AIGC products. However, it is challenging to provide optimal AIGC services in wireless networks with unstable channels, limited bandwidth resources, and unevenly distributed computational resources. To tackle these challenges, we propose a semantic communication (SemCom)-empowered AIGC (SemAIGC) generation and transmission framework, where only semantic information of the content rather than all the binary bits should be extracted and transmitted by using SemCom. Specifically, SemAIGC integrates diffusion-based models within the semantic encoder and decoder for efficient content generation and flexible adjustment of the computing workload of both transmitter and receiver. Meanwhile, we devise a resource-aware workload trade-off (ROOT) scheme into the SemAIGC framework to intelligently decide transmitter/receiver workload, thus adjusting the utilization of computational resource according to service requirements. Simulations verify the superiority of our proposed SemAIGC framework in terms of latency and content quality compared to conventional approaches.