The method of importance map has been widely adopted in DNN-based lossy image compression to achieve bit allocation according to the importance of image contents. However, insufficient allocation of bits in non-important regions often leads to severe distortion at low bpp (bits per pixel), which hampers the development of efficient content-weighted image compression systems. This paper rethinks content-based compression by using Generative Adversarial Network (GAN) to reconstruct the non-important regions. Moreover, multiscale pyramid decomposition is applied to both the encoder and the discriminator to achieve global compression of high-resolution images. A tunable compression scheme is also proposed in this paper to compress an image to any specific compression ratio without retraining the model. The experimental results show that our proposed method improves MS-SSIM by more than 10.3% compared to the recently reported GAN-based method to achieve the same low bpp (0.05) on the Kodak dataset.