Despite the transformative impact of deep learning (DL) on wireless communication systems through data-driven end-to-end (E2E) learning, the security vulnerabilities of these systems have been largely overlooked. Unlike the extensively studied image domain, limited research has explored the threat of backdoor attacks on the reconstruction of symbols in semantic communication (SemCom) systems. Previous work has investigated such backdoor attacks at the input level, but these approaches are infeasible in applications with strict input control. In this paper, we propose a novel attack paradigm, termed Channel-Triggered Backdoor Attack (CT-BA), where the backdoor trigger is a specific wireless channel. This attack leverages fundamental physical layer characteristics, making it more covert and potentially more threatening compared to previous input-level attacks. Specifically, we utilize channel gain with different fading distributions or channel noise with different power spectral densities as potential triggers. This approach establishes unprecedented attack flexibility as the adversary can select backdoor triggers from both fading characteristics and noise variations in diverse channel environments. Moreover, during the testing phase, CT-BA enables automatic trigger activation through natural channel variations without requiring active adversary participation. We evaluate the robustness of CT-BA on a ViT-based Joint Source-Channel Coding (JSCC) model across three datasets: MNIST, CIFAR-10, and ImageNet. Furthermore, we apply CT-BA to three typical E2E SemCom systems: BDJSCC, ADJSCC, and JSCCOFDM. Experimental results demonstrate that our attack achieves near-perfect attack success rate (ASR) while maintaining effective stealth. Finally, we discuss potential defense mechanisms against such attacks.