AMMASurv: Asymmetrical Multi-Modal Attention for Accurate Survival Analysis with Whole Slide Images and Gene Expression Data

The use of multi-modal data such as the combination of whole slide images (WSIs) and gene expression data for survival analysis can lead to more accurate survival predictions. Previous multi-modal survival models are not able to efficiently excavate the intrinsic information within each modality. Moreover, despite experimental results show that WSIs provide more effective information than gene expression data, previous methods regard the information from different modalities as similarly important so they cannot flexibly utilize the potential connection between the modalities. To address the above problems, we propose a new asymmetrical multi-modal method, termed as AMMASurv. Specifically, we design an asymmetrical multi-modal attention mechanism (AMMA) in Transformer encoder for multi-modal data to enable a more flexible multi-modal information fusion for survival prediction. Different from previous works, AMMASurv can effectively utilize the intrinsic information within every modality and flexibly adapts to the modalities of different importance. Extensive experiments are conducted to validate the effectiveness of the proposed model. Encouraging results demonstrate the superiority of our method over other state-of-the-art methods.