Uncertainty Quantification in Neural-Network Based Pain Intensity Estimation

Improper pain management can lead to severe physical or mental consequences, including suffering, and an increased risk of opioid dependency. Assessing the presence and severity of pain is imperative to prevent such outcomes and determine the appropriate intervention. However, the evaluation of pain intensity is challenging because different individuals experience pain differently. To overcome this, researchers have employed machine learning models to evaluate pain intensity objectively. However, these efforts have primarily focused on point estimation of pain, disregarding the inherent uncertainty and variability present in the data and model. Consequently, the point estimates provide only partial information for clinical decision-making. This study presents a neural network-based method for objective pain interval estimation, incorporating uncertainty quantification. This work explores three algorithms: the bootstrap method, lower and upper bound estimation (LossL) optimized by genetic algorithm, and modified lower and upper bound estimation (LossS) optimized by gradient descent algorithm. Our empirical results reveal that LossS outperforms the other two by providing a narrower prediction interval. As LossS outperforms, we assessed its performance in three different scenarios for pain assessment: (1) a generalized approach (single model for the entire population), (2) a personalized approach (separate model for each individual), and (3) a hybrid approach (separate model for each cluster of individuals). Our findings demonstrate the hybrid approach's superior performance, with notable practicality in clinical contexts. It has the potential to be a valuable tool for clinicians, enabling objective pain intensity assessment while taking uncertainty into account. This capability is crucial in facilitating effective pain management and reducing the risks associated with improper treatment.

Transformer Encoder with Multiscale Deep Learning for Pain Classification Using Physiological Signals

Pain is a serious worldwide health problem that affects a vast proportion of the population. For efficient pain management and treatment, accurate classification and evaluation of pain severity are necessary. However, this can be challenging as pain is a subjective sensation-driven experience. Traditional techniques for measuring pain intensity, e.g. self-report scales, are susceptible to bias and unreliable in some instances. Consequently, there is a need for more objective and automatic pain intensity assessment strategies. In this paper, we develop PainAttnNet (PAN), a novel transfomer-encoder deep-learning framework for classifying pain intensities with physiological signals as input. The proposed approach is comprised of three feature extraction architectures: multiscale convolutional networks (MSCN), a squeeze-and-excitation residual network (SEResNet), and a transformer encoder block. On the basis of pain stimuli, MSCN extracts short- and long-window information as well as sequential features. SEResNet highlights relevant extracted features by mapping the interdependencies among features. The third module employs a transformer encoder consisting of three temporal convolutional networks (TCN) with three multi-head attention (MHA) layers to extract temporal dependencies from the features. Using the publicly available BioVid pain dataset, we test the proposed PainAttnNet model and demonstrate that our outcomes outperform state-of-the-art models. These results confirm that our approach can be utilized for automated classification of pain intensity using physiological signals to improve pain management and treatment.

Multi-Scales Data Augmentation Approach In Natural Language Inference For Artifacts Mitigation And Pre-Trained Model Optimization

Machine learning models can reach high performance on benchmark natural language processing (NLP) datasets but fail in more challenging settings. We study this issue when a pre-trained model learns dataset artifacts in natural language inference (NLI), the topic of studying the logical relationship between a pair of text sequences. We provide a variety of techniques for analyzing and locating dataset artifacts inside the crowdsourced Stanford Natural Language Inference (SNLI) corpus. We study the stylistic pattern of dataset artifacts in the SNLI. To mitigate dataset artifacts, we employ a unique multi-scale data augmentation technique with two distinct frameworks: a behavioral testing checklist at the sentence level and lexical synonym criteria at the word level. Specifically, our combination method enhances our model's resistance to perturbation testing, enabling it to continuously outperform the pre-trained baseline.

Review and Analysis of Pain Research Literature through Keyword Co-occurrence Networks

Pain is a significant public health problem as the number of individuals with a history of pain globally keeps growing. In response, many synergistic research areas have been coming together to address pain-related issues. This work conducts a review and analysis of a vast body of pain-related literature using the keyword co-occurrence network (KCN) methodology. In this method, a set of KCNs is constructed by treating keywords as nodes and the co-occurrence of keywords as links between the nodes. Since keywords represent the knowledge components of research articles, analysis of KCNs will reveal the knowledge structure and research trends in the literature. This study extracted and analyzed keywords from 264,560 pain-related research articles indexed in IEEE, PubMed, Engineering Village, and Web of Science published between 2002 and 2021. We observed rapid growth in pain literature in the last two decades: the number of articles has grown nearly threefold, and the number of keywords has grown by a factor of 7. We identified emerging and declining research trends in sensors/methods, biomedical, and treatment tracks. We also extracted the most frequently co-occurring keyword pairs and clusters to help researchers recognize the synergies among different pain-related topics.

Brief Introduction to Contrastive Learning Pretext Tasks for Visual Representation

To improve performance in visual feature representation from photos or videos for practical applications, we generally require large-scale human-annotated labeled data while training deep neural networks. However, the cost of gathering and annotating human-annotated labeled data is expensive. Given that there is a lot of unlabeled data in the actual world, it is possible to introduce self-defined pseudo labels as supervisions to prevent this issue. Self-supervised learning, specifically contrastive learning, is a subset of unsupervised learning methods that has grown popular in computer vision, natural language processing, and other domains. The purpose of contrastive learning is to embed augmented samples from the same sample near to each other while pushing away those that are not. In the following sections, we will introduce the regular formulation among different learnings. In the next sections, we will discuss the regular formulation of various learnings. Furthermore, we offer some strategies from contrastive learning that have recently been published and are focused on pretext tasks for visual representation.