Generalized Robust Fundus Photography-based Vision Loss Estimation for High Myopia

High myopia significantly increases the risk of irreversible vision loss. Traditional perimetry-based visual field (VF) assessment provides systematic quantification of visual loss but it is subjective and time-consuming. Consequently, machine learning models utilizing fundus photographs to estimate VF have emerged as promising alternatives. However, due to the high variability and the limited availability of VF data, existing VF estimation models fail to generalize well, particularly when facing out-of-distribution data across diverse centers and populations. To tackle this challenge, we propose a novel, parameter-efficient framework to enhance the generalized robustness of VF estimation on both in- and out-of-distribution data. Specifically, we design a Refinement-by-Denoising (RED) module for feature refinement and adaptation from pretrained vision models, aiming to learn high-entropy feature representations and to mitigate the domain gap effectively and efficiently. Through independent validation on two distinct real-world datasets from separate centers, our method significantly outperforms existing approaches in RMSE, MAE and correlation coefficient for both internal and external validation. Our proposed framework benefits both in- and out-of-distribution VF estimation, offering significant clinical implications and potential utility in real-world ophthalmic practices.

Boosting of Implicit Neural Representation-based Image Denoiser

Implicit Neural Representation (INR) has emerged as an effective method for unsupervised image denoising. However, INR models are typically overparameterized; consequently, these models are prone to overfitting during learning, resulting in suboptimal results, even noisy ones. To tackle this problem, we propose a general recipe for regularizing INR models in image denoising. In detail, we propose to iteratively substitute the supervision signal with the mean value derived from both the prediction and supervision signal during the learning process. We theoretically prove that such a simple iterative substitute can gradually enhance the signal-to-noise ratio of the supervision signal, thereby benefiting INR models during the learning process. Our experimental results demonstrate that INR models can be effectively regularized by the proposed approach, relieving overfitting and boosting image denoising performance.