Labeling subtypes in a Parkinson's Cohort using Multifeatures in MRI -- Integrating Grey and White Matter Information

Thresholding of networks has long posed a challenge in brain connectivity analysis. Weighted networks are typically binarized using threshold measures to facilitate network analysis. Previous studies on MRI-based brain networks have predominantly utilized density or sparsity-based thresholding techniques, optimized within specific ranges derived from network metrics such as path length, clustering coefficient, and small-world index. Thus, determination of a single threshold value for facilitating comparative analysis of networks remains elusive. To address this, our study introduces Mutual K-Nearest Neighbor (MKNN)-based thresholding for brain network analysis. Here, nearest neighbor selection is based on the highest correlation between features of brain regions. Construction of brain networks was accomplished by computing Pearson correlations between grey matter volume and white matter volume for each pair of brain regions. Structural MRI data from 180 Parkinsons patients and 70 controls from the NIMHANS, India were analyzed. Subtypes within Parkinsons disease were identified based on grey and white matter volume atrophy using source-based morphometric decomposition. The loading coefficients were correlated with clinical features to discern clinical relationship with the deciphered subtypes. Our data-mining approach revealed: Subtype A (N = 51, intermediate type), Subtype B (N = 57, mild-severe type with mild motor symptoms), and Subtype AB (N = 36, most-severe type with predominance in motor impairment). Subtype-specific weighted matrices were binarized using MKNN-based thresholding for brain network analysis. Permutation tests on network metrics of resulting bipartite graphs demonstrated significant group differences in betweenness centrality and participation coefficient. The identified hubs were specific to each subtype, with some hubs conserved across different subtypes.

Visualization of Unstructured Sports Data -- An Example of Cricket Short Text Commentary

Sports visualization focuses on the use of structured data, such as box-score data and tracking data. Unstructured data sources pertaining to sports are available in various places such as blogs, social media posts, and online news articles. Sports visualization methods either not fully exploited the information present in these sources or the proposed visualizations through the use of these sources did not augment to the body of sports visualization methods. We propose the use of unstructured data, namely cricket short text commentary for visualization. The short text commentary data is used for constructing individual player's strength rules and weakness rules. A computationally feasible definition for player's strength rule and weakness rule is proposed. A visualization method for the constructed rules is presented. In addition, players having similar strength rules or weakness rules is computed and visualized. We demonstrate the usefulness of short text commentary in visualization by analyzing the strengths and weaknesses of cricket players using more than one million text commentaries. We validate the constructed rules through two validation methods. The collected data, source code, and obtained results on more than 500 players are made publicly available.