Bioimpedance a Diagnostic Tool for Tobacco Induced Oral Lesions: a Mixed Model cross-sectional study

Introduction: Electrical impedance spectroscopy (EIS) has recently developed as a novel diagnostic device for screening and evaluating cervical dysplasia, prostate cancer, breast cancer and basal cell carcinoma. The current study aimed to validate and evaluate bioimpedance as a diagnostic tool for tobacco-induced oral lesions. Methodology: The study comprised 50 OSCC and OPMD tissue specimens for in-vitro study and 320 subjects for in vivo study. Bioimpedance device prepared and calibrated. EIS measurements were done for the habit and control groups and were compared. Results: The impedance value in the control group was significantly higher compared to the OPMD and OSCC groups. Diagnosis based on BIS measurements has a sensitivity of 95.9% and a specificity of 86.7%. Conclusion: Bioimpedance device can help in decision-making for differentiating OPMD and OSCC cases and their management, especially in primary healthcare settings. Keywords: Impedance, Cancer, Diagnosis, Device, Community