Feasibility Analysis of Fifth-generation (5G) Mobile Networks for Transmission of Medical Imaging Data

Next to higher data rates and lower latency, the upcoming fifth-generation mobile network standard will introduce a new service ecosystem. Concepts such as multi-access edge computing or network slicing will enable tailoring service level requirements to specific use-cases. In medical imaging, researchers and clinicians are currently working towards higher portability of scanners. This includes i) small scanners to be wheeled inside the hospital to the bedside and ii) conventional scanners provided via trucks to remote areas. Both use-cases introduce the need for mobile networks adhering to high safety standards and providing high data rates. These requirements could be met by fifth-generation mobile networks. In this work, we analyze the feasibility of transferring medical imaging data using the current state of development of fifth-generation mobile networks (3GPP Release 15). We demonstrate the potential of reaching 100 Mbit/s upload rates using already available consumer-grade hardware. Furthermore, we show an effective average data throughput of 50 Mbit/s when transferring medical images using out-of-the-box open-source software based on the Digital Imaging and Communications in Medicine (DICOM) standard. During transmissions, we sample the radio frequency bands to analyse the characteristics of the mobile radio network. Additionally, we discuss the potential of new features such as network slicing that will be introduced in forthcoming releases.

Edge computing in 5G cellular networks for real-time analysis of electrocardiography recorded with wearable textile sensors

Fifth-generation (5G) cellular networks promise higher data rates, lower latency, and large numbers of interconnected devices. Thereby, 5G will provide important steps towards unlocking the full potential of the Internet of Things (IoT). In this work, we propose a lightweight IoT platform for continuous vital sign analysis. Electrocardiography (ECG) is acquired via textile sensors and continuously sent from a smartphone to an edge device using cellular networks. The edge device applies a state-of-the art deep learning model for providing a binary end-to-end classification if a myocardial infarction is at hand. Using this infrastructure, experiments with four volunteers were conducted. We compare 3rd, 4th-, and 5th-generation cellular networks (release 15) with respect to transmission latency, data corruption, and duration of machine learning inference. The best performance is achieved using 5G showing an average transmission latency of 110ms and data corruption in 0.07% of ECG samples. Deep learning inference took approximately 170ms. In conclusion, 5G cellular networks in combination with edge devices are a suitable infrastructure for continuous vital sign analysis using deep learning models. Future 5G releases will introduce multi-access edge computing (MEC) as a paradigm for bringing edge devices nearer to mobile clients. This will decrease transmission latency and eventually enable automatic emergency alerting in near real-time.

Mesh-to-raster based non-rigid registration of multi-modal images

Region of interest (ROI) alignment in medical images plays a crucial role in diagnostics, procedure planning, treatment, and follow-up. Frequently, a model is represented as triangulated mesh while the patient data is provided from CAT scanners as pixel or voxel data. Previously, we presented a 2D method for curve-to-pixel registration. This paper contributes (i) a general mesh-to-raster (M2R) framework to register ROIs in multi-modal images; (ii) a 3D surface-to-voxel application, and (iii) a comprehensive quantitative evaluation in 2D using ground truth provided by the simultaneous truth and performance level estimation (STAPLE) method. The registration is formulated as a minimization problem where the objective consists of a data term, which involves the signed distance function of the ROI from the reference image, and a higher order elastic regularizer for the deformation. The evaluation is based on quantitative light-induced fluoroscopy (QLF) and digital photography (DP) of decalcified teeth. STAPLE is computed on 150 image pairs from 32 subjects, each showing one corresponding tooth in both modalities. The ROI in each image is manually marked by three experts (900 curves in total). In the QLF-DP setting, our approach significantly outperforms the mutual information-based registration algorithm implemented with the Insight Segmentation and Registration Toolkit (ITK) and Elastix.