Deep Learning Based HPV Status Prediction for Oropharyngeal Cancer Patients

We investigated the ability of deep learning models for imaging based HPV status detection. To overcome the problem of small medical datasets we used a transfer learning approach. A 3D convolutional network pre-trained on sports video clips was fine tuned such that full 3D information in the CT images could be exploited. The video pre-trained model was able to differentiate HPV-positive from HPV-negative cases with an area under the receiver operating characteristic curve (AUC) of 0.81 for an external test set. In comparison to a 3D convolutional neural network (CNN) trained from scratch and a 2D architecture pre-trained on ImageNet the video pre-trained model performed best.

Shape optimization in laminar flow with a label-guided variational autoencoder

Computational design optimization in fluid dynamics usually requires to solve non-linear partial differential equations numerically. In this work, we explore a Bayesian optimization approach to minimize an object's drag coefficient in laminar flow based on predicting drag directly from the object shape. Jointly training an architecture combining a variational autoencoder mapping shapes to latent representations and Gaussian process regression allows us to generate improved shapes in the two dimensional case we consider.