OmniCellTOSG: The First Cell Text-Omic Signaling Graphs Dataset for Joint LLM and GNN Modeling

Complex cell signaling systems -- governed by varying protein abundances and interactions -- generate diverse cell types across organs. These systems evolve under influences such as age, sex, diet, environmental exposures, and diseases, making them challenging to decode given the involvement of tens of thousands of genes and proteins. Recently, hundreds of millions of single-cell omics data have provided a robust foundation for understanding these signaling networks within various cell subpopulations and conditions. Inspired by the success of large foundation models (for example, large language models and large vision models) pre-trained on massive datasets, we introduce OmniCellTOSG, the first dataset of cell text-omic signaling graphs (TOSGs). Each TOSG represents the signaling network of an individual or meta-cell and is labeled with information such as organ, disease, sex, age, and cell subtype. OmniCellTOSG offers two key contributions. First, it introduces a novel graph model that integrates human-readable annotations -- such as biological functions, cellular locations, signaling pathways, related diseases, and drugs -- with quantitative gene and protein abundance data, enabling graph reasoning to decode cell signaling. This approach calls for new joint models combining large language models and graph neural networks. Second, the dataset is built from single-cell RNA sequencing data of approximately 120 million cells from diverse tissues and conditions (healthy and diseased) and is fully compatible with PyTorch. This facilitates the development of innovative cell signaling models that could transform research in life sciences, healthcare, and precision medicine. The OmniCellTOSG dataset is continuously expanding and will be updated regularly. The dataset and code are available at https://github.com/FuhaiLiAiLab/OmniCellTOSG.

Don't Listen To Me: Understanding and Exploring Jailbreak Prompts of Large Language Models

Recent advancements in generative AI have enabled ubiquitous access to large language models (LLMs). Empowered by their exceptional capabilities to understand and generate human-like text, these models are being increasingly integrated into our society. At the same time, there are also concerns on the potential misuse of this powerful technology, prompting defensive measures from service providers. To overcome such protection, jailbreaking prompts have recently emerged as one of the most effective mechanisms to circumvent security restrictions and elicit harmful content originally designed to be prohibited. Due to the rapid development of LLMs and their ease of access via natural languages, the frontline of jailbreak prompts is largely seen in online forums and among hobbyists. To gain a better understanding of the threat landscape of semantically meaningful jailbreak prompts, we systemized existing prompts and measured their jailbreak effectiveness empirically. Further, we conducted a user study involving 92 participants with diverse backgrounds to unveil the process of manually creating jailbreak prompts. We observed that users often succeeded in jailbreak prompts generation regardless of their expertise in LLMs. Building on the insights from the user study, we also developed a system using AI as the assistant to automate the process of jailbreak prompt generation.