Localized Motion Artifact Reduction on Brain MRI Using Deep Learning with Effective Data Augmentation Techniques

In-scanner motion degrades the quality of magnetic resonance imaging (MRI) thereby reducing its utility in the detection of clinically relevant abnormalities. We introduce a deep learning-based MRI artifact reduction model (DMAR) to localize and correct head motion artifacts in brain MRI scans. Our approach integrates the latest advances in object detection and noise reduction in Computer Vision. Specifically, DMAR employs a two-stage approach: in the first, degraded regions are detected using the Single Shot Multibox Detector (SSD), and in the second, the artifacts within the found regions are reduced using a convolutional autoencoder (CAE). We further introduce a set of novel data augmentation techniques to address the high dimensionality of MRI images and the scarcity of available data. As a result, our model was trained on a large synthetic dataset of 217,000 images generated from six whole-brain T1-weighted MRI scans obtained from three subjects. DMAR produces convincing visual results when applied to both synthetic test images and 55 real-world motion-affected slices from 18 subjects from the multi-center Autism Brain Imaging Data Exchange study. Quantitatively, depending on the level of degradation, our model achieves a 14.3%-25.6% reduction in RMSE and a 1.38-2.68 dB gain in PSNR on a 5000-sample set of synthetic images. For real-world scans where the ground-truth is unavailable, our model produces a 3.65% reduction in regional standard deviations of image intensity.