Open-Source Periorbital Segmentation Dataset for Ophthalmic Applications

Periorbital segmentation and distance prediction using deep learning allows for the objective quantification of disease state, treatment monitoring, and remote medicine. However, there are currently no reports of segmentation datasets for the purposes of training deep learning models with sub mm accuracy on the regions around the eyes. All images (n=2842) had the iris, sclera, lid, caruncle, and brow segmented by five trained annotators. Here, we validate this dataset through intra and intergrader reliability tests and show the utility of the data in training periorbital segmentation networks. All the annotations are publicly available for free download. Having access to segmentation datasets designed specifically for oculoplastic surgery will permit more rapid development of clinically useful segmentation networks which can be leveraged for periorbital distance prediction and disease classification. In addition to the annotations, we also provide an open-source toolkit for periorbital distance prediction from segmentation masks. The weights of all models have also been open-sourced and are publicly available for use by the community.

State-of-the-Art Periorbital Distance Prediction and Disease Classification Using Periorbital Features

Periorbital distances and features around the eyes and lids hold valuable information for disease quantification and monitoring of surgical and medical intervention. These distances are commonly measured manually, a process that is both subjective and highly time-consuming. Here, we set out to developed three deep-learning methods for segmentation and periorbital distance prediction, and also evaluate the utility of periorbital distances for disease classification. The MAE of our deep learning predicted distances was less than or very close to the error observed between trained human annotators. We compared our models to the current state-of-the-art (SOTA) method for periorbital distance prediction and found that our methods outperformed SOTA on all of our datasets on all but one periorbital measurement. We also show that robust segmentation can be achieved on diseased eyes using models trained on open-source, healthy eyes, and that periorbital distances have can be used as high-quality features in downstream classification models. Leveraging segmentation networks as intermediary steps in classification has broad implications for increasing the generalizability of classification models in ophthalmic plastic and craniofacial surgery by avoiding the out-of-distribution problem observed in traditional convolutional neural networks.

AutoPtosis

Blepharoptosis, or ptosis as it is more commonly referred to, is a condition of the eyelid where the upper eyelid droops. The current diagnosis for ptosis involves cumbersome manual measurements that are time-consuming and prone to human error. In this paper, we present AutoPtosis, an artificial intelligence based system with interpretable results for rapid diagnosis of ptosis. We utilize a diverse dataset collected from the Illinois Ophthalmic Database Atlas (I-ODA) to develop a robust deep learning model for prediction and also develop a clinically inspired model that calculates the marginal reflex distance and iris ratio. AutoPtosis achieved 95.5% accuracy on physician verified data that had an equal class balance. The proposed algorithm can help in the rapid and timely diagnosis of ptosis, significantly reduce the burden on the healthcare system, and save the patients and clinics valuable resources.