A Comprehensive Review of U-Net and Its Variants: Advances and Applications in Medical Image Segmentation

Medical images often exhibit low and blurred contrast between lesions and surrounding tissues, with considerable variation in lesion edges and shapes even within the same disease, leading to significant challenges in segmentation. Therefore, precise segmentation of lesions has become an essential prerequisite for patient condition assessment and formulation of treatment plans. Significant achievements have been made in research related to the U-Net model in recent years. It improves segmentation performance and is extensively applied in the semantic segmentation of medical images to offer technical support for consistent quantitative lesion analysis methods. First, this paper classifies medical image datasets on the basis of their imaging modalities and then examines U-Net and its various improvement models from the perspective of structural modifications. The research objectives, innovative designs, and limitations of each approach are discussed in detail. Second, we summarize the four central improvement mechanisms of the U-Net and U-Net variant algorithms: the jump-connection mechanism, residual-connection mechanism, 3D-UNet, and transformer mechanism. Finally, we examine the relationships among the four core enhancement mechanisms and commonly utilized medical datasets and propose potential avenues and strategies for future advancements. This paper provides a systematic summary and reference for researchers in related fields, and we look forward to designing more efficient and stable medical image segmentation network models based on the U-Net network.

A 3M-Hybrid Model for the Restoration of Unique Giant Murals: A Case Study on the Murals of Yongle Palace

The Yongle Palace murals, as valuable cultural heritage, have suffered varying degrees of damage, making their restoration of significant importance. However, the giant size and unique data of Yongle Palace murals present challenges for existing deep-learning based restoration methods: 1) The distinctive style introduces domain bias in traditional transfer learning-based restoration methods, while the scarcity of mural data further limits the applicability of these methods. 2) Additionally, the giant size of these murals results in a wider range of defect types and sizes, necessitating models with greater adaptability. Consequently, there is a lack of focus on deep learning-based restoration methods for the unique giant murals of Yongle Palace. Here, a 3M-Hybrid model is proposed to address these challenges. Firstly, based on the characteristic that the mural data frequency is prominent in the distribution of low and high frequency features, high and low frequency features are separately abstracted for complementary learning. Furthermore, we integrate a pre-trained Vision Transformer model (VIT) into the CNN module, allowing us to leverage the benefits of a large model while mitigating domain bias. Secondly, we mitigate seam and structural distortion issues resulting from the restoration of large defects by employing a multi-scale and multi-perspective strategy, including data segmentation and fusion. Experimental results demonstrate the efficacy of our proposed model. In regular-sized mural restoration, it improves SSIM and PSNR by 14.61% and 4.73%, respectively, compared to the best model among four representative CNN models. Additionally, it achieves favorable results in the final restoration of giant murals.