Prompt Engineering a Schizophrenia Chatbot: Utilizing a Multi-Agent Approach for Enhanced Compliance with Prompt Instructions

Patients with schizophrenia often present with cognitive impairments that may hinder their ability to learn about their condition. These individuals could benefit greatly from education platforms that leverage the adaptability of Large Language Models (LLMs) such as GPT-4. While LLMs have the potential to make topical mental health information more accessible and engaging, their black-box nature raises concerns about ethics and safety. Prompting offers a way to produce semi-scripted chatbots with responses anchored in instructions and validated information, but prompt-engineered chatbots may drift from their intended identity as the conversation progresses. We propose a Critical Analysis Filter for achieving better control over chatbot behavior. In this system, a team of prompted LLM agents are prompt-engineered to critically analyze and refine the chatbot's response and deliver real-time feedback to the chatbot. To test this approach, we develop an informational schizophrenia chatbot and converse with it (with the filter deactivated) until it oversteps its scope. Once drift has been observed, AI-agents are used to automatically generate sample conversations in which the chatbot is being enticed to talk about out-of-bounds topics. We manually assign to each response a compliance score that quantifies the chatbot's compliance to its instructions; specifically the rules about accurately conveying sources and being transparent about limitations. Activating the Critical Analysis Filter resulted in an acceptable compliance score (>=2) in 67.0% of responses, compared to only 8.7% when the filter was deactivated. These results suggest that a self-reflection layer could enable LLMs to be used effectively and safely in mental health platforms, maintaining adaptability while reliably limiting their scope to appropriate use cases.

AI Driven Knowledge Extraction from Clinical Practice Guidelines: Turning Research into Practice

Background and Objectives: Clinical Practice Guidelines (CPGs) represent the foremost methodology for sharing state-of-the-art research findings in the healthcare domain with medical practitioners to limit practice variations, reduce clinical cost, improve the quality of care, and provide evidence based treatment. However, extracting relevant knowledge from the plethora of CPGs is not feasible for already burdened healthcare professionals, leading to large gaps between clinical findings and real practices. It is therefore imperative that state-of-the-art Computing research, especially machine learning is used to provide artificial intelligence based solution for extracting the knowledge from CPGs and reducing the gap between healthcare research/guidelines and practice. Methods: This research presents a novel methodology for knowledge extraction from CPGs to reduce the gap and turn the latest research findings into clinical practice. First, our system classifies the CPG sentences into four classes such as condition-action, condition-consequences, action, and not-applicable based on the information presented in a sentence. We use deep learning with state-of-the-art word embedding, improved word vectors technique in classification process. Second, it identifies qualifier terms in the classified sentences, which assist in recognizing the condition and action phrases in a sentence. Finally, the condition and action phrase are processed and transformed into plain rule If Condition(s) Then Action format. Results: We evaluate the methodology on three different domains guidelines including Hypertension, Rhinosinusitis, and Asthma. The deep learning model classifies the CPG sentences with an accuracy of 95%. While rule extraction was validated by user-centric approach, which achieved a Jaccard coefficient of 0.6, 0.7, and 0.4 with three human experts extracted rules, respectively.

A Practical Approach towards Causality Mining in Clinical Text using Active Transfer Learning

Objective: Causality mining is an active research area, which requires the application of state-of-the-art natural language processing techniques. In the healthcare domain, medical experts create clinical text to overcome the limitation of well-defined and schema driven information systems. The objective of this research work is to create a framework, which can convert clinical text into causal knowledge. Methods: A practical approach based on term expansion, phrase generation, BERT based phrase embedding and semantic matching, semantic enrichment, expert verification, and model evolution has been used to construct a comprehensive causality mining framework. This active transfer learning based framework along with its supplementary services, is able to extract and enrich, causal relationships and their corresponding entities from clinical text. Results: The multi-model transfer learning technique when applied over multiple iterations, gains performance improvements in terms of its accuracy and recall while keeping the precision constant. We also present a comparative analysis of the presented techniques with their common alternatives, which demonstrate the correctness of our approach and its ability to capture most causal relationships. Conclusion: The presented framework has provided cutting-edge results in the healthcare domain. However, the framework can be tweaked to provide causality detection in other domains, as well. Significance: The presented framework is generic enough to be utilized in any domain, healthcare services can gain massive benefits due to the voluminous and various nature of its data. This causal knowledge extraction framework can be used to summarize clinical text, create personas, discover medical knowledge, and provide evidence to clinical decision making.