Renal Cell Carcinoma subtyping: learning from multi-resolution localization

Renal Cell Carcinoma is typically asymptomatic at the early stages for many patients. This leads to a late diagnosis of the tumor, where the curability likelihood is lower, and makes the mortality rate of Renal Cell Carcinoma high, with respect to its incidence rate. To increase the survival chance, a fast and correct categorization of the tumor subtype is paramount. Nowadays, computerized methods, based on artificial intelligence, represent an interesting opportunity to improve the productivity and the objectivity of the microscopy-based Renal Cell Carcinoma diagnosis. Nonetheless, much of their exploitation is hampered by the paucity of annotated dataset, essential for a proficient training of supervised machine learning technologies. This study sets out to investigate a novel self supervised training strategy for machine learning diagnostic tools, based on the multi-resolution nature of the histological samples. We aim at reducing the need of annotated dataset, without significantly reducing the accuracy of the tool. We demonstrate the classification capability of our tool on a whole slide imaging dataset for Renal Cancer subtyping, and we compare our solution with several state-of-the-art classification counterparts.

FedOS: using open-set learning to stabilize training in federated learning

Federated Learning is a recent approach to train statistical models on distributed datasets without violating privacy constraints. The data locality principle is preserved by sharing the model instead of the data between clients and the server. This brings many advantages but also poses new challenges. In this report, we explore this new research area and perform several experiments to deepen our understanding of what these challenges are and how different problem settings affect the performance of the final model. Finally, we present a novel approach to one of these challenges and compare it to other methods found in literature.