Collaborative learning of common latent representations in routinely collected multivariate ICU physiological signals

In Intensive Care Units (ICU), the abundance of multivariate time series presents an opportunity for machine learning (ML) to enhance patient phenotyping. In contrast to previous research focused on electronic health records (EHR), here we propose an ML approach for phenotyping using routinely collected physiological time series data. Our new algorithm integrates Long Short-Term Memory (LSTM) networks with collaborative filtering concepts to identify common physiological states across patients. Tested on real-world ICU clinical data for intracranial hypertension (IH) detection in patients with brain injury, our method achieved an area under the curve (AUC) of 0.889 and average precision (AP) of 0.725. Moreover, our algorithm outperforms autoencoders in learning more structured latent representations of the physiological signals. These findings highlight the promise of our methodology for patient phenotyping, leveraging routinely collected multivariate time series to improve clinical care practices.

VAE-IF: Deep feature extraction with averaging for unsupervised artifact detection in routine acquired ICU time-series

Artifacts are a common problem in physiological time-series data collected from intensive care units (ICU) and other settings. They affect the quality and reliability of clinical research and patient care. Manual annotation of artifacts is costly and time-consuming, rendering it impractical. Automated methods are desired. Here, we propose a novel unsupervised approach to detect artifacts in clinical-standard minute-by-minute resolution ICU data without any prior labeling or signal-specific knowledge. Our approach combines a variational autoencoder (VAE) and an isolation forest (iForest) model to learn features and identify anomalies in different types of vital signs, such as blood pressure, heart rate, and intracranial pressure. We evaluate our approach on a real-world ICU dataset and compare it with supervised models based on long short-term memory (LSTM) and XGBoost. We show that our approach achieves comparable sensitivity and generalizes well to an external dataset. We also visualize the latent space learned by the VAE and demonstrate its ability to disentangle clean and noisy samples. Our approach offers a promising solution for cleaning ICU data in clinical research and practice without the need for any labels whatsoever.