A Review on Generative AI Models for Synthetic Medical Text, Time Series, and Longitudinal Data

This paper presents the results of a novel scoping review on the practical models for generating three different types of synthetic health records (SHRs): medical text, time series, and longitudinal data. The innovative aspects of the review, which incorporate study objectives, data modality, and research methodology of the reviewed studies, uncover the importance and the scope of the topic for the digital medicine context. In total, 52 publications met the eligibility criteria for generating medical time series (22), longitudinal data (17), and medical text (13). Privacy preservation was found to be the main research objective of the studied papers, along with class imbalance, data scarcity, and data imputation as the other objectives. The adversarial network-based, probabilistic, and large language models exhibited superiority for generating synthetic longitudinal data, time series, and medical texts, respectively. Finding a reliable performance measure to quantify SHR re-identification risk is the major research gap of the topic.

Accurate Detection of Paroxysmal Atrial Fibrillation with Certified-GAN and Neural Architecture Search

This paper presents a novel machine learning framework for detecting Paroxysmal Atrial Fibrillation (PxAF), a pathological characteristic of Electrocardiogram (ECG) that can lead to fatal conditions such as heart attack. To enhance the learning process, the framework involves a Generative Adversarial Network (GAN) along with a Neural Architecture Search (NAS) in the data preparation and classifier optimization phases. The GAN is innovatively invoked to overcome the class imbalance of the training data by producing the synthetic ECG for PxAF class in a certified manner. The effect of the certified GAN is statistically validated. Instead of using a general-purpose classifier, the NAS automatically designs a highly accurate convolutional neural network architecture customized for the PxAF classification task. Experimental results show that the accuracy of the proposed framework exhibits a high value of 99% which not only enhances state-of-the-art by up to 5.1%, but also improves the classification performance of the two widely-accepted baseline methods, ResNet-18, and Auto-Sklearn, by 2.2% and 6.1%.