Performance of a large language model-Artificial Intelligence based chatbot for counseling patients with sexually transmitted infections and genital diseases

Introduction: Global burden of sexually transmitted infections (STIs) is rising out of proportion to specialists. Current chatbots like ChatGPT are not tailored for handling STI-related concerns out of the box. We developed Otiz, an Artificial Intelligence-based (AI-based) chatbot platform designed specifically for STI detection and counseling, and assessed its performance. Methods: Otiz employs a multi-agent system architecture based on GPT4-0613, leveraging large language model (LLM) and Deterministic Finite Automaton principles to provide contextually relevant, medically accurate, and empathetic responses. Its components include modules for general STI information, emotional recognition, Acute Stress Disorder detection, and psychotherapy. A question suggestion agent operates in parallel. Four STIs (anogenital warts, herpes, syphilis, urethritis/cervicitis) and 2 non-STIs (candidiasis, penile cancer) were evaluated using prompts mimicking patient language. Each prompt was independently graded by two venereologists conversing with Otiz as patient actors on 6 criteria using Numerical Rating Scale ranging from 0 (poor) to 5 (excellent). Results: Twenty-three venereologists did 60 evaluations of 30 prompts. Across STIs, Otiz scored highly on diagnostic accuracy (4.1-4.7), overall accuracy (4.3-4.6), correctness of information (5.0), comprehensibility (4.2-4.4), and empathy (4.5-4.8). However, relevance scores were lower (2.9-3.6), suggesting some redundancy. Diagnostic scores for non-STIs were lower (p=0.038). Inter-observer agreement was strong, with differences greater than 1 point occurring in only 12.7% of paired evaluations. Conclusions: AI conversational agents like Otiz can provide accurate, correct, discrete, non-judgmental, readily accessible and easily understandable STI-related information in an empathetic manner, and can alleviate the burden on healthcare systems.

AI enhanced diagnosis of Peyronies disease a novel approach using Computer Vision

This study presents an innovative AI-driven tool for diagnosing Peyronie's Disease (PD), a condition that affects between 0.3% and 13.1% of men worldwide. Our method uses key point detection on both images and videos to measure penile curvature angles, utilizing advanced computer vision techniques. This tool has demonstrated high accuracy in identifying anatomical landmarks, validated against conventional goniometer measurements. Traditional PD diagnosis often involves subjective and invasive methods, which can lead to patient discomfort and inaccuracies. Our approach offers a precise, reliable, and non-invasive diagnostic tool to address these drawbacks. The model distinguishes between PD and normal anatomical changes with a sensitivity of 96.7% and a specificity of 100%. This advancement represents a significant improvement in urological diagnostics, greatly enhancing the efficacy and convenience of PD assessment for healthcare providers and patients.

Mpox Detection Advanced: Rapid Epidemic Response Through Synthetic Data

Rapid development of disease detection models using computer vision is crucial in responding to medical emergencies, such as epidemics or bioterrorism events. Traditional data collection methods are often too slow in these scenarios, requiring innovative approaches for quick, reliable model generation from minimal data. Our study introduces a novel approach by constructing a comprehensive computer vision model to detect Mpox lesions using only synthetic data. Initially, these models generated a diverse set of synthetic images representing Mpox lesions on various body parts (face, back, chest, leg, neck, arm) across different skin tones as defined by the Fitzpatrick scale (fair, brown, dark skin). Subsequently, we trained and tested a vision model with this synthetic dataset to evaluate the diffusion models' efficacy in producing high-quality training data and its impact on the vision model's medical image recognition performance. The results were promising; the vision model achieved a 97% accuracy rate, with 96% precision and recall for Mpox cases, and similarly high metrics for normal and other skin disorder cases, demonstrating its ability to correctly identify true positives and minimize false positives. The model achieved an F1-Score of 96% for Mpox cases and 98% for normal and other skin disorders, reflecting a balanced precision-recall relationship, thus ensuring reliability and robustness in its predictions. Our proposed SynthVision methodology indicates the potential to develop accurate computer vision models with minimal data input for future medical emergencies.

SynthVision -- Harnessing Minimal Input for Maximal Output in Computer Vision Models using Synthetic Image data

Rapid development of disease detection computer vision models is vital in response to urgent medical crises like epidemics or events of bioterrorism. However, traditional data gathering methods are too slow for these scenarios necessitating innovative approaches to generate reliable models quickly from minimal data. We demonstrate our new approach by building a comprehensive computer vision model for detecting Human Papilloma Virus Genital warts using only synthetic data. In our study, we employed a two phase experimental design using diffusion models. In the first phase diffusion models were utilized to generate a large number of diverse synthetic images from 10 HPV guide images explicitly focusing on accurately depicting genital warts. The second phase involved the training and testing vision model using this synthetic dataset. This method aimed to assess the effectiveness of diffusion models in rapidly generating high quality training data and the subsequent impact on the vision model performance in medical image recognition. The study findings revealed significant insights into the performance of the vision model trained on synthetic images generated through diffusion models. The vision model showed exceptional performance in accurately identifying cases of genital warts. It achieved an accuracy rate of 96% underscoring its effectiveness in medical image classification. For HPV cases the model demonstrated a high precision of 99% and a recall of 94%. In normal cases the precision was 95% with an impressive recall of 99%. These metrics indicate the model capability to correctly identify true positive cases and minimize false positives. The model achieved an F1 Score of 96% for HPV cases and 97% for normal cases. The high F1 Score across both categories highlights the balanced nature of the model precision and recall ensuring reliability and robustness in its predictions.